The Department of Health and Human Services, National Institutes of Health are seeking applications for its grant programme entitled "Drug Delivery Strategies for HIV" to support studies with a focus on developing drug delivery strategies that target the Central Nervous System (CNS) for better suppression of Human Immunodeficiency Virus (HIV) and reservoir reduction.

Areas of Interest

• CNS targeting formulations of existing antiretrovirals known to have poor CNS penetration. Formulations may involve polymers, nanoparticles, liposomes, and other agents that will increase concentrations of antiretrovirals in CNS compartments and provide an acceptable balance between efficacy and safety.
• Formulations with the ability to carry large molecules (e.g., broadly neutralizing antibodies, bi-specific antibodies, etc.) to the CNS for HIV inactivation or for purging of the CNS reservoir.
• Drug delivery platforms that use current antiretrovirals in combination with transporters, immunomodulators, and other agents that will result in improvements in activity in the CNS.

Award Project Period

• The scope of the proposed project should determine the project period.
• The maximum project period is 5 years.

Eligibility Criteria

• Higher Education Institutions
  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education
• The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
• Nonprofits Other Than Institutions of Higher Education
  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
• For-Profit Organizations
  • Small Businesses
  • For-Profit Organizations (Other than Small Businesses)
• Governments
  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
  • Eligible Agencies of the Federal Government
  • U.S. Territory or Possession
• Other
  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American Tribal Organizations (other than Federally recognized tribal governments)
  • Faith-based or Community-based Organizations
  • Regional Organizations
  • Non-domestic (non-U.S.) Entities (Foreign Institutions)
• Foreign Institutions
  • Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply
  • Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

How to Apply

Applicants can apply via given website.

For further information, please visit Grants.gov.