The Kavli Trust Programme on Health Research will be awarding a total of NOK 20 M in 2021 to collaborative research projects addressing selected evidence gaps in child and adolescent mental health. Mental health problems in children and adolescents make up a considerable part of today’s global disease burden but funding for research addressing these problems is sparse compared to most somatic illnesses. For a variety of reasons a significant part of today’s health research is wasted and Kavli Trust is committed to limiting research waste by anchoring research funding in established and prioritized evidence gaps The evidence gaps were selected in three steps: The Kavli Trust Strategic Scientific Committee (SSC) identified evidence gaps by searching for systematic reviews in selected databases The Kavli Trust User Panel provided their prioritization of the evidence gaps Kavli Trust decided on how many of the top-ranked evidence gaps to include in the call. The 10 Evidence Gaps What is the effect of interventions for children who have been subjected to abuse and neglect or have experienced violence in close relationships? What is the effect of interventions on bullying and cyberbullying among children and adolescents? What is the effect of interventions to reduce loneliness in children and adolescents? What is the effect of mental health care interventions in child welfare? What is the effect of non-pharmacological treatments for children and adolescents with ADHD? What is the effect of psychological and psychosocial interventions for children and adolescents with post-traumatic stress disorder? What is the effect of psychological interventions to improve emotion regulation in adolescents? What is the effect of psychosocial interventions for school refusal? What is the effect of psychosocial interventions in adolescents exposed to mass trauma? What is the effect of school-based psychosocial interventions to promote mental health in children and adolescents? Eligibility Criteria To be eligible for funding, the projects must meet all the following criteria: The research project must address one or more of the selected evidence gaps. The formal applicant has to be an university, academic institution or research institution or institute in Norway, Sweden, Finland or the United Kingdom (host institution). The principal investigator must have a formal affiliation to the host institution. The research project can not apply for less than NOK 3 M or more than NOK 10 M in total for the project period. Funding from the Kavli Trust cannot be used for overhead and/or other expenses not directly related to the project. The host institution must provide a considerable in-kind contribution. In the full proposal a commitment letter signed by the head of the institution, describing the nature and level of its contribution to the project must be attached. The maximum project duration is six years. The research project must commit to user involvement by including two named user representatives as members of the research group. The proposal and the attachments have to be written in English. The host institution must accept the following demands if the proposal is granted: The agreement is regulated by Norwegian law. All payments will be made in NOK and the host institution bears the risk associated with varying exchange rates. All studies must be pre-registered, either in EUCTR, ClinicalTrials.gov or OSF.io. Submittal of annual reports including an audited accounting report, done by an independent accountant or auditor. Publications must be in accordance with the ICMJE recommendations and the CONSORT statement. Unrestricted open access to the published output of research is a requirement. For more information, visit Kavli Trust.